Hachim D., Daniel

Profesor Asistente

email djhachim@uc.cl

phone (56) 95504 5878

Ph.D. in Bioengineering. Tissue Engineering and Regenerative Medicine Track
University of Pittsburgh (Pittsburgh, PA, USA), 2017

Perfil en ORCID

En mi Laboratorio de Tecnologías Biomimeticas estamos enfocados al desarrollo y el estudio de:

1) El desarrollo y estudio de sustitutos de tejidos por medio bioimpresión 3D de hidrogeles y scaffolds que imiten la arquitectura y/o funcionalidad de los tejidos con fines de regeneración.
2) Vehículos farmacéuticos inteligentes (smart drug delivery systems) para la liberación de factores de crecimiento, citokinas y ácidos nucleicos en el organismo.
3) Desarrollo y estudio de plataformas organ-on-a-chip.
4) Biomateriales bioresponsivos a estímulos fisiopatológicos. Ejemplos de estos estímulos incluyen pH, temperatura y radicales de oxígeno.
5) Ingeniería de superficies y recubrimientos aplicado a prótesis e implantes médicos.

- Química General
- Tecnología Farmaceutica I
- Tecnología Farmacéutica II

Mimicking de osteochondral tissue via hierarchically structured hydrogels for joint repair.
Investigador Responsable.
Fondecyt de Iniciación 11240633, ANID

Untangling the gut-brain axis via multi- organ-on-a-chip.
Co-investigador.
Interstellar Initiative, Japan Agency for Medical Research and Development and the New York Academy of Sciences.

Conductive, self-doping and biodegradable oligoEDOT-heparin biomaterial for improved electromechanical coupling, cardiac cell retention and delivery of paracrine factors.
Investigador Responsable.
Marie Skłodowska-Curie Actions 839111, European Commission.

Self‐Doped and Biodegradable Glycosaminoglycan‐PEDOT Conductive Hydrogels Facilitate Electrical Pacing of iPSC‐Derived Cardiomyocytes.
Hachim, D.; Hernández‐Cruz, O.; Foote, J.E.J.; Richard Wang, R.; Delahaye, M.W.; Stuckey, D.J.; Feng, Z.; Wojciechowski, J.P.; Salter, L.C.B.; Lin, J.; Harding, S.E.; Stevens, M.M.
Advanced Healthcare Materials (2025).

Polysaccharide-Polyplex Nanofilm Coatings Enhance Nanoneedle-Based Gene Delivery and Transfection Efficiency.
Hachim, D.; Zhao, J.; Bhankharia, J.; Nuñez-Toldra, R.; Brito, L.; Seong, H.; Becce, M.; Ouyang, L.; Grigsby, C.L.; Higgins, S.G.; Terracciano, C.M.; Stevens, M.M.
Small (2022).

Expanding and optimizing 3D bioprinting capabilities using complementary network bioinks.
Ouyang, L.; Armstrong, J.P.K.; Lin, Y.; Wojciechowski, J.P.; Lee-Reeves, C.; Hachim, D.; Zhou, K.; Burdick, J.A.; Stevens, M.M.
Science Advances (2020).

Distinct release strategies are required to modulate macrophage phenotype in young versus aged animals.
Hachim, D.; Iftikhar, A.; LoPresti, S.T.; Nolfi, A.L.; Ravichandar, S.; Skillen, C.D.; Brown, B.N.
Journal of Controlled Release (2019).

Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration.
Hachim, D.; LoPresti, S.T.; Yates, C.C.; Brown, B.N.
Biomaterials (2017).

Mas destacados:

2018 - 1st Prize Award for Best Poster Presentation at the 8th Annual Department of Materials Postdoc Symposium 2018, Imperial College, London, UK.

2017 - 1st place Poster Competition at Regenerative Medicine Workshop 2017, Hilton Head Island, SC.

2016 - 2nd place in 2016 TERMIS-AM Business Competition, December 11th - 14th, San Diego, CA.

2016 - 2nd place in the Wells Healthcare Business Competition (US$ 10,000), Pittsburgh, PA.

2016 - NSF I-Corps Program Award for “Layer-Up”. University of Pittsburgh, PA.

• Stevens Group exhibition committee. Great Exhibition Road Festival, London, United Kingdom.
• Volunteer exhibitor. London International Young Science Forum (LIYSF).
• Session organizer. Exploring options after your degree. Panel discussion at the Society for Biomaterials Conference, April 2018, Atlanta.
• President, Society for Biomaterials (SFB) United States National Student Council.
• Student Representative and Webmaster, Society for Biomaterials, Drug Delivery SIG.
• Newsletter Chair, Biomedical Engineering Society Chapter (BMES), University of Pittsburgh.

Congresos (seleccionados):

• Hachim D*, Foote J, Hernández O, Delahaye M, Ouyang L, Wang R, Harding SE, Stevens MM. Glycosaminoglycan-PEDOT conductive hydrogels for iPSC-derived cardiomyocyte implantation and electrical coupling. 7th International Bioelectronics Conference 2022. Tirol, Austria.
• Hachim D*, Zhao J, Bhankaria J, Nuñez-Toldra R, Brito L, Seong H, Becce M, Grigsby C, Terracciano C, Stevens MM. Polysaccharide-polyplex ultrathin coatings for nanoneedle-based gene delivery. Tissue Engineering and Regenerative Medicine International Society (TERMIS) - World Conference 2021 (Podium presentation). Maastricht, Netherlands.
• Hachim D*, Mylonaki I, Dondi C, Stuckey D, Brito L, Harding SE, Stevens MM. Injectable memory-shape cryogels for minimally invasive delivery of cardiac progenitors into the heart. 11th World Biomaterials Congress (Podium presentation). December 2020. Glasgow, Scotland, United Kingdom.
• Hachim D*, LoPresti ST, Brown BN. Development of a Cytokine-Loaded Layer by Layer Coating on Polypropylene Meshes to Modulate Macrophage Polarization at the Tissue-Implant Interface. Society for Biomaterials (Podium presentation), April 2015. Charlotte, NC, United States.