Información general

Pessoa M., C. David
Director de Gestión Académica
Profesor Titular

Doctor en Ciencias Exactas, mención Química
Pontificia Universidad Católica de Chile, 1998

Perfil en ORCID

Líneas de Investigación

Síntesis de moduladores químicos del sistema endocannabinoide.

Docencia

QIF101A   Fármaco-Química I
QPG3326 Química Medicinal

Proyectos

Synthesis, binding mode prediction, biological evaluation and sar analysis of benzoimidazole-based modulators of the endocannabinoid system. 
Investigador Principal.
Fondecyt Regular 1150121, ANID.

Synthesis and structure-activity relationships studies of novel cb1 receptor ligands. 
Investigador Principal.
Fondecyt Regular 1100493, ANID.

Busqueda de nuevos inhibidores no nucleosidicos de la enzima transcriptasa reversa de hiv-1: sintesis y evaluacion biologica de nuevos derivados benzoimidazolicos. 
Investigador Principal.
Fondecyt Regular 1050950, ANID.


 

Publicaciones

Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9tetrahydrocannabinol: An in Silico study.
Chung, H., Fierro, A., Pessoa-Mahana, C. D.
 PLoS One (2019).

Three-dimensional quantitative structure-activity relationships (3D-QSAR) on a series of piperazine-carboxamides fatty acid amide hydrolase (FAAH) inhibitors as a useful tool for the design of new cannabinoid ligands.
Lorca, M., Valdes, Y., Chung, H., Romero-Parra, J., Pessoa-Mahana, C. D., Mella, J.
International Journal of Molecular Sciences (2019).

Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.
Romero-Parra, J., Chung, H., Tapia, R. A., Faúndez, M., Morales-Verdejo, C., Lorca, M., Lagos, C. F., Di Marzo, V., Pessoa-Mahana, C. D., Mella, J.
European Journal of Pharmaceutical Sciences (2017).

Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor.
Romero-Parra, J., Mella-Raipán, J., Palmieri, V., Allarà, M., Torres, M. J., Pessoa-Mahana, H., Iturriaga-Vásquez, P., Escobar, R., Faúndez, M., Di Marzo, V., Pessoa-Mahana, C.D.
European Journal of Medicinal Chemistry (2016).

3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity Relationships of Aminoalkylindoles in the Cannabinoid CB1 and CB2 Receptors.
Mella-Raipán, J., Hernández-Pino, S., Morales-Verdejo, C., Pessoa-Mahana, D. 
Molecules (2014).