• Serie de Actividades
    Serie de Actividades

    Para celebrar el Año internacional de la Tabla Periódica, la Facultad tiene organizada diversas actividades que buscan plasmar a la química como una ciencia central y a la Tabla Periódica como un instrumento fundamental para el desarrollo científico y tecnológico de la humanidad.

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  • Asegurando la disponibilidad de alimentos para una creciente población
    Asegurando la disponibilidad de alimentos para una creciente población

    De apetito voraz y predilección por las verduras crucíferas como el brócoli, coliflor y repollo, el gusano medidor del repollo (Trichoplusia ni) provoca un grave daño económico y medioambiental...

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  • Impulsando la educación científica

    La Tabla Periódica Interactiva (TPI) es una plataforma de difusión e interacción desarrollada por la Facultad de Química...

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  • CEQUC

    Fundado en 1982, el Centro de Ensayos y Estudios Externos de Química ha prestado servicios de estudios y análisis químicos...

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Recabarren G., Gonzalo

Recabarren Gajardo, Gonzalo

 

Gonzalo Recabarren G.
Phone: (56-2) 2354 1418
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Assistant Professor
PhD in Chemistry
Universidad de Chile, 2008

 

 

 

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The research group of the "Bioactive Heterocycles Synthesis" laboratory focuses mainly on the development (design, synthesis and pharmacological evaluation) of 5-HT1A and 5-HT6 receptor antagonists as potential agents against obesity, cancer, anxiety, depression and Alzheimer’s disease, among others ailments. To carry out these objectives we collaborate with researchers of the Department of Pharmacy and other academic centers, studying permeability and solubility properties, and determining the molecules’ biopharmaceutical profile, with the aim of selecting those that possess suitable drug-like properties.

We also have collaborations with faculty from UC and other universities, with whom we evaluate the molecules in terms of activity and toxicity in in vivo models such as vinegar fly (Drosophila melanogaster) and zebrafish (Danio rerio) as a pharmacologically relevant approach to higher animal models.

A further research line focuses on the development of synthetic methodology of biologically relevant heterocycles such as indazole, indole and azaindole. To this end we have established a close collaboration with a research group in the Université de Caen Normandie where our group’s PhD students can carry out their research stay.

As secondary research lines we collaborate with a group of the Faculty of Medicine of our University in the development of inhibitors of 11β-HSD1 for the treatment of hypertension and metabolic syndrome.
Specifically, we perform the synthesis of these compounds. Lastly, a line of collaborative research is maintained with a group from the Adolfo Ibañez University where we carry out the structural elucidation of bacterial metabolites of environmentally relevant species.

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